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Cancer screening,[link widoczny dla zalogowanych]
Ovarian cancer is notoriously hard to detect,[link widoczny dla zalogowanych], with many women's cancers only being noticed when they're so advanced that recovery is not likely. A group of National Cancer Institute researchers is focusing on a blood test that will detect ovarian cancer by looking at the pattern of all the proteins inside a woman's blood. Not too long ago,[link widoczny dla zalogowanych], they reported the technique worked quite well,[link widoczny dla zalogowanych], better than another screening options; within this study, they're refining the exam.
What the researchers desired to know: Will high-resolution mass spectrometry (hang on,[link widoczny dla zalogowanych], it seems sensible even though you do not know what that means) get this to test more accurate?
What they did: The researchers got 248 blood serum samples from the National Ovarian Cancer Early Detection Program and the gynecologic oncology clinic at Northwestern University. The samples were bonded to tiny chips so that they might be processed quickly,[link widoczny dla zalogowanych], one to another. Each sample is processed by running it through a mass spectrometer,[link widoczny dla zalogowanych], a piece of equipment that measures the mass of molecules as they fly through it to generate a protein profile for that sample. They actually used two different kinds of mass spectrometers,[link widoczny dla zalogowanych], one with higher resolution can give more specific details about the proteins in the sample. Then the researchers used computers to investigate the patterns for differences between normal liquid blood samples and samples from women with ovarian cancer. Finally,[link widoczny dla zalogowanych], those computer models might be accustomed to try to distinguish normal blood from ovarian cancer blood in another set of samples.
What they found: While using high-resolution machine, they could tell normal blood and ovarian cancer patients' blood apart every single time. That's pretty good and than they could do using the lower-resolution mass spectrometer.
What the study way to you: This sort of analysis chips,[link widoczny dla zalogowanych], lasers,[link widoczny dla zalogowanych], and tons of high-tech equipment an encouraging new method to screen for cancer.
Caveats: It'll be some time before this test is fast,[link widoczny dla zalogowanych], easy,[link widoczny dla zalogowanych], cheap,[link widoczny dla zalogowanych], and reliable enough to use it in each and every diagnostic lab on the planet.
Find out more: The nation's Cancer Institute's proteomics programs,[link widoczny dla zalogowanych], where this research was conducted. The organization Proteome Systems's website has a long article explaining what proteins are and why you need to worry about proteins and proteomics.
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